On Wednesday morning, 67 companies achieved new lows for the year.

Areas of Significance:

• Grifols (NASDAQ:GRFS) was the largest firm by market cap to set a new 52-week low.
• GreenVision Acquisition (NASDAQ:GRNV) was the smallest company in terms of market cap to set a new 52-week low.
• AppHarvest (NASDAQ:APPH)'s stock dropped the most, trading down 33.67% to reach a new 52-week low.

During the first half-hour of trading on Wednesday, the following stocks set new 52-week lows:

• Grifols (NASDAQ:GRFS) stock drifted up 0.54% on Wednesday morning to hit a new 52-week low of $14.66.
• Neurocrine Biosciences (NASDAQ:NBIX) shares set a new yearly low of $85.82 this morning. The stock was down 1.18% on the session.
• TuSimple Hldgs (NASDAQ:TSP) stock achieved a new 52-week low on Wednesday morning, hitting $30.81 and moving down 3.09%.
• Amedisys (NASDAQ:AMED) shares hit a yearly low of $190.26. The stock was down 1.55% on the session.
• Pan American Silver (NASDAQ:PAAS) stock set a new 52-week low of $24.95 on Wednesday, moving up 3.29%.
• Skillz (NYSE:SKLZ) shares moved down 0.95% on Wednesday to hit a new 52-week low of $11.84, drifting down 0.95%.
• Q2 Holdings (NYSE:QTWO) stock set a new 52-week low of $82.80 on Wednesday, moving down 1.02%.
• 1Life Healthcare (NASDAQ:ONEM) stock set a new 52-week low of $24.19 on Wednesday, moving down 1.86%.
• Arena Pharmaceuticals (NASDAQ:ARNA) stock dropped to a yearly low on Wednesday of $50.91. Shares traded down 0.71%.
• Oscar Health (NYSE:OSCR) shares moved down 2.68% on Wednesday to hit a new 52-week low of $14.55, drifting down 2.68%.
• Nektar Therapeutics (NASDAQ:NKTR) stock drifted down 0.97% on Wednesday morning to hit a new 52-week low of $14.62.
• GoHealth (NASDAQ:GOCO) shares hit a yearly low of $8.37. The stock was down 1.86% on the session.
• Grocery Outlet Holding (NASDAQ:GO) shares were down 12.42% for the day, having made a 52-week low of $26.92.
• Poshmark (NASDAQ:POSH) shares hit a yearly low of $28.50. The stock was down 9.5% on the session.
• InnovAge Holding (NASDAQ:INNV) stock hit $15.69 on Wednesday morning, setting a new 52-week low for a change of down 1.76%.
• Nuvation Bio (NYSE:NUVB) shares were down 1.87% for the day, having made a 52-week low of $8.04.
• Root (NASDAQ:ROOT) stock hit $6.79 on Wednesday morning, setting a new 52-week low for a change of up 0.73%.
• Outset Medical (NASDAQ:OM) stock drifted down 1.71% on Wednesday morning to hit a new 52-week low of $36.03.
• Hims & Hers Health (NYSE:HIMS) shares set a new yearly low of $7.31 this morning. The stock was down 4.97% on the session.
• eHealth (NASDAQ:EHTH) shares set a new 52-week low of $47.26. The stock traded down 1.62%.
• Singular Genomics Systems (NASDAQ:OMIC) shares were down 0.82% for the day, having made a 52-week low of $15.01.
• Kura Oncology (NASDAQ:KURA) shares made a new 52-week low of $16.66 on Wednesday. The stock was down 0.94% for the day.
• ON24 (NYSE:ONTF) shares were down 28.49% for the day, having made a 52-week low of $21.50.
• Lordstown Motors (NASDAQ:RIDE) stock hit $5.65 on Wednesday morning, setting a new 52-week low for a change of down 2.38%.
• New Gold (AMEX:NGD) shares fell to $1.36 on Wednesday, setting a new 52-week low with a shift of down 0.35%.
• Nautilus Biotechnology (NASDAQ:NAUT) shares set a new yearly low of $7.20 this morning. The stock was down 2.51% on the session.
• Kiniksa Pharmaceuticals (NASDAQ:KNSA) shares set a new 52-week low of $12.32. The stock traded down 1.11%.
• AppHarvest (NASDAQ:APPH) shares moved down 33.67% on Wednesday to hit a new 52-week low of $7.52, drifting down 33.67%.
• Zogenix (NASDAQ:ZGNX) shares made a new 52-week low of $13.81 on Wednesday. The stock was down 1.06% for the day.
• Talkspace (NASDAQ:TALK) stock set a new 52-week low of $4.60 on Wednesday, moving down 3.82%.
• CareMax (NASDAQ:CMAX) stock set a new 52-week low of $8.15 on Wednesday, moving up 2.75%.
• Akero Therapeutics (NASDAQ:AKRO) shares moved down 1.04% on Wednesday to hit a new 52-week low of $19.11, drifting down 1.04%.
• EverQuote (NASDAQ:EVER) stock set a new 52-week low of $22.05 on Wednesday, moving down 1.37%.
• Trillium Therapeutics (NASDAQ:TRIL) stock hit $6.12 on Wednesday morning, setting a new 52-week low for a change of down 3.13%.
• Home Point Capital (NASDAQ:HMPT) stock achieved a new 52-week low on Wednesday morning, hitting $4.51 and moving down 0.44%.
• Seres Therapeutics (NASDAQ:MCRB) stock hit a new 52-week low of $6.60. The stock was down 1.04% on the session.
• Epizyme (NASDAQ:EPZM) shares set a new 52-week low of $5.46. The stock traded up 0.73%.
• Vasta Platform (NASDAQ:VSTA) shares made a new 52-week low of $6.25 on Wednesday. The stock was down 2.34% for the day.
• Cementos Pacasmayo (NYSE:CPAC) stock achieved a new 52-week low on Wednesday morning, hitting $5.54 and moving down 1.26%.
• iClick Interactive Asia (NASDAQ:ICLK) stock hit a new 52-week low of $4.77. The stock was down 1.64% on the session.
• TherapeuticsMD (NASDAQ:TXMD) stock achieved a new 52-week low on Wednesday morning, hitting $0.90 and moving down 0.4%.
• Relmada Therapeutics (NASDAQ:RLMD) shares set a new yearly low of $20.60 this morning. The stock was down 8.04% on the session.
• VectoIQ Acquisition Corp (NASDAQ:VTIQ) shares moved up 0.31% on Wednesday to hit a new 52-week low of $9.61, drifting up 0.31%.
• CytomX Therapeutics (NASDAQ:CTMX) shares set a new 52-week low of $4.83. The stock traded up 1.83%.
• Harpoon Therapeutics (NASDAQ:HARP) stock hit $9.00 on Wednesday morning, setting a new 52-week low for a change of down 2.45%.
• Avrobio (NASDAQ:AVRO) shares set a new 52-week low of $5.85. The stock traded down 0.3%.
• Eros STX Global (NYSE:ESGC) shares were down 4.86% for the day, having made a 52-week low of $0.63.
• Kamada (NASDAQ:KMDA) shares set a new 52-week low of $5.28. The stock traded down 5.34%.
• Adicet Bio (NASDAQ:ACET) shares set a new yearly low of $6.81 this morning. The stock was down 1.51% on the session.
• Biodesix (NASDAQ:BDSX) stock hit a new 52-week low of $7.85. The stock was down 17.38% on the session.
• Talis Biomedical (NASDAQ:TLIS) stock broke to a new 52-week low of $7.52 on Wednesday. Shares of the company traded down 8.7%.
• TFF Pharmaceuticals (NASDAQ:TFFP) shares moved down 2.45% on Wednesday to hit a new 52-week low of $7.38, drifting down 2.45%.
• E-Home Household Service (NASDAQ:EJH) shares set a new 52-week low of $4.55. The stock traded down 6.35%.
• Americas Gold And Silver (AMEX:USAS) stock hit $1.22 on Wednesday morning, setting a new 52-week low for a change of down 1.6%.
• Huize Holding (NASDAQ:HUIZ) stock hit a yearly low of $3.07. The stock was down 2.34% for the day.
• Spok Holdings (NASDAQ:SPOK) shares set a new yearly low of $7.51 this morning. The stock was down 0.79% on the session.
• Sio Gene Therapies (NASDAQ:SIOX) shares hit a yearly low of $1.92. The stock was up 0.25% on the session.
• OptiNose (NASDAQ:OPTN) stock hit $2.50 on Wednesday morning, setting a new 52-week low for a change of down 2.26%.
• Pop Culture Gr (NASDAQ:CPOP) stock broke to a new 52-week low of $4.70 on Wednesday. Shares of the company traded down 0.41%.
• Viridian Therapeutics (NASDAQ:VRDN) shares moved down 2.86% on Wednesday to hit a new 52-week low of $12.89, drifting down 2.86%.
• Eton Pharmaceuticals (NASDAQ:ETON) stock dropped to a yearly low on Wednesday of $4.38. Shares traded down 0.44%.
• Fury Gold Mines (AMEX:FURY) stock drifted down 0.12% on Wednesday morning to hit a new 52-week low of $0.87.
• Otonomy (NASDAQ:OTIC) shares made a new 52-week low of $1.54 on Wednesday. The stock was down 0.42% for the day.
• Baudax Bio (NASDAQ:BXRX) stock achieved a new 52-week low on Wednesday morning, hitting $0.53 and moving down 3.09%.
• Happiness Biotech Gr (NASDAQ:HAPP) shares set a new 52-week low of $1.19. The stock traded down 1.72%.
• MEDIROM Healthcare (NASDAQ:MRM) shares hit a yearly low of $6.70. The stock was down 1.9% on the session.
• GreenVision Acquisition (NASDAQ:GRNV) shares were down 5.04% for the day, having made a 52-week low of $8.29.

Benzinga will continue to update investors on these equities. Stay tuned for further news.