Preclinical Phase

VYNE Therapeutics Inc (NASDAQ: VYNE) announced positive preclinical data from its VYN201 program in the rheumatoid arthritis (RA) animal model. The Company will start a first-in-human trial for VYN201 in 2H of 2022. VYN201 demonstrated marked inhibition of paw thickening at the 1...

Regulus Therapeutics Inc (NASDAQ: RGLS) has initiated studies to evaluate a library of oligonucleotides to block miR-155 for Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease) under a collaboration agreement with Harvard's Brigham and Women's Hospital (BWH)....

Allogene Therapeutics Inc (NASDAQ: ALLO) announced the publication of preclinical study results demonstrating the superior long-term in vitro myeloma-killing activity of allogeneic anti-BCMA CAR T cells from healthy donors compared with cells from multiple myeloma patients...

Sorrento Therapeutics Inc (NASDAQ: SRNE) announced the publication of a preprint entitled "Chimeric mRNA based COVID-19 vaccine induces protective immunity against Omicron and Delta." Serum collected from omicron-specific mRNA vaccine immunized animals provided superior...

Seres Therapeutics Inc (NASDAQ: MCRB) will present preclinical findings at the European Bone Marrow Transplantation (EBMT) Annual Meeting. The data suggest that SER-155 targets the host immune response, potentially allowing patients undergoing hematopoietic stem cell transplantation (HSCT) to...

Stealth BioTherapeutics Corp (NASDAQ: MITO) presented new data demonstrating the potential synergistic relationship between elamipretide and an exon-skipping phosphorodiamidate morpholino oligomer (PMO) in the X-linked muscular dystrophy (mdx) animal model.  The data were...

Prothena Corporation plc (NASDAQ: PRTA) presented new preclinical data from its dual Aβ/tau and tandem C-terminal α-synuclein vaccine programs in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively.  The data were presented at the...

Gain Therapeutics Inc (NASDAQ: GANX) has presented new preclinical data from its Parkinson's and Alzheimer's Disease programs.  These results were highlighted at the International Conference on Alzheimer's (AD) and Parkinson's Diseases (PD).  The data shows...

NeuBase Therapeutics Inc (NASDAQ: NBSE) announced new preclinical data for its lead development candidate, NT-0231.F, to treat myotonic dystrophy type 1 (DM1), a multisystem disorder that affects skeletal and smooth muscle. A single intramuscular dose confirmed that NT-0231.F is...

The FDA has lifted the clinical hold on Immunome Inc's (NASDAQ: IMNM) Investigational New Drug (IND) application for its antibody cocktail (IMM-BCP-01) to treat COVID-19.  Immunome previously announced that the FDA had placed its IND application on clinical hold...

Oragenics Inc (NYSE: OGEN) has entered into an agreement with KBI Biopharma Inc for the process transfer, process optimization, and cGMP manufacturing of its intranasal vaccine candidate NT-CoV2-1.  The agreement covers, among other things, both a 200L demonstration...

Immunoprecise Antibodies Ltd (NASDAQ: IPA) has reported preclinical data of PolyTope TATX-03 antibody cocktail therapy against COVID-19. The IND-enabling animal studies did not show any observable acute adverse events and supported a favorable safety profile. As a prelude to a formal...

VYNE Therapeutics Inc (NASDAQ: VYNE) has announced preclinical data in an ex vivo skin model of vitiligo, a chronic autoimmune depigmenting disorder of the skin. In the preclinical model, pan-bromodomain and extra-terminal (BET) inhibitor VYN201 reduced the expression of...

Chimerix Inc's (NASDAQ: CMRX) preclinical data from its CMX521 program will be featured at the International Conference on Antiviral Research (ICAR) in March. In vivo, studies were performed in an animal model used during the development of a different antiviral therapy that obtained...

Aridis Pharmaceuticals Inc's (NASDAQ: ARDS) fully human monoclonal antibodies (mAbs) in the AR-701 cocktail has been shown to neutralize the SARS-CoV-2 omicron variant.  Both mAbs conferred complete protection against Omicron infected animals when given either parenterally or by...