Mid-Day Top-5 and Bottom-5 Percentage Gainers (MSSR, CRYP, COOL, OREX, AEN, AMIE, DGW, HRZ, RVSN, TPI)

After opening slightly to the upside, the major indices have been meandering around neutral territory for most of the day. Traders are seemingly unsure as they assess the continuing rise in oil and commodities and evaluate the potential impact on the economy. Here are the five best/worst performers thus far:

Best

1) McCormick & Schmick's Seafood Restaurants (NASDAQ: MSSR): Currently trading up 29% to $9.21 after Landry's Restaurants CEO Tilman Fertitta revealed plans to launch a hostile takeover of the high end seafood restaurant.

2) CryptoLogic (NASDAQ: CRYP): No news has come to light as shares have rocketed 17.49% to $1.84 on heavy volume, beginning at 11:10 a.m. EST.

3) Majesco Entertainment Company (NASDAQ: COOL): Running off of Facebook hype, the stock is enjoying a 16.7% climb to $3.83 in today's trade. Shares in this interactive entertainment company have vaulted 106% in the last month.

4) Orexigen Therapeutics (NASDAQ: OREX): Positive data emanating from phase three trials of its weight loss drug, Contrave, are pushing the stock up 15.97% to $3.35.

5) Adeona Pharamaceuticals (Amex: AEN): Shares are currently 15% higher to $2.15 as traders react to a positive earnings report and conference call on Friday.

Worst

1) Ambassadors International (NASDAQ: AMIE): The travel and cruise services company is undergoing a massive 71% hit to $0.80this morning. The parent of Windstar Cruises filed for bankruptcy protection on Friday.

2) Duoyuan Global Water (NYSE: DGW): Shares are extending their early morning losses f 22.4% to $4.28 after a negative report from muddywaterresearch.com surfaced.

3) Horizon Lines (NYSE: HRZ): After recovering from an early morning selloff, stock of this shipping services company are once again selling off in the late morning, taking a 18.79% loss to $1.08.

4) RADVision (NASDAQ: RVSN): Shares are down over 16% to $10.02 as the video conferencing equipment company cut its guidance for the first quarter.

5) Tianyin Pharmaceutical Co. (AMEX: TPI): No news has come to light for this company, but shares have taken a 10.36% plunge to $1.99 this morning. The stock is down 23% in the past five trading days.