Solid Tumor

IDEAYA Biosciences Inc (NASDAQ: IDYA) has announced interim Phase 1 data for IDE397 in patients with solid tumors with methylthioadenosine phosphorylase (MTAP) deletion, estimated to represent approximately 15% of solid tumors. The observed steady-state plasma SAM exceeds the target...

Adagene Inc (NASDAQ: ADAG) announced clinical data on ADG116, and ADG106, in two poster presentations at the European Society for Medical Oncology Immuno-Oncology (ESMO-IO) Congress 2021. ADG116 monotherapy in Phase 1 study was well-tolerated up to 6 mg/kg with only mild or moderate...

Immunocore Holdings Plc (NASDAQ: IMCR) announced the initial Phase 1 data of IMC-C103C, a bispecific T cell engager targeting MAGE-A4, in selected advanced solid tumors. IMC-C103C was developed using the Company's ImmTAC technology platform and is being developed in partnership...

SQZ Biotechnologies Company (NYSE: SQZ) announced interim results from the highest-dose monotherapy cohort of Phase 1/2 trial of SQZ-PBMC-HPV in Human Papillomavirus positive (HPV16+) solid tumors.  The investigational cell therapy is being evaluated in certain patients with...

Mereo BioPharma Group plc (NASDAQ: MREO) reported interim data from ACTIVATE Phase 1b/2 study of its anti-TIGIT antibody, etigilimab, in combination with Bristol Myers Squibb Co (NYSE: BMY) Opdivo (nivolumab) in select recurrent advanced/metastatic solid tumors. As of the...

The FDA has cleared Adagene Inc's (NASDAQ: ADAG) Investigational New Drug (IND) application to proceed with a Phase 1b/2 trial of ADG116, in combination with Merck & Co Inc (NYSE: MRK) Keytruda (pembrolizumab).  The global trial (ADG116-P001 / KEYNOTE-C97)...

Codiak BioSciences Inc (NASDAQ: CDAK) announced initial data for exoSTING currently in a Phase 1/2 trial as a single agent for the treatment of multiple solid tumors. ExoSTING is an engineered exosome therapeutic candidate. In the first three dose cohorts of the trial, participants...

Iovance Biotherapeutics Inc (NASDAQ: IOVA) has announced data for lifileucel in combination with Merck Co Inc's (NYSE: MRK) Keytruda (pembrolizumab) in patients with advanced cancers. Data were presented at the Society for Immunotherapy of Cancer Annual Meeting. Early-...

Moderna Inc (NASDAQ: MRNA) announced interim data from Phase 1 study of mRNA-2752 (Triplet) in patients with accessible solid tumors and lymphomas.  The data showed that the mRNA Triplet program given in combination with AstraZeneca Plc's (NASDAQ: AZN) Imfinzi (durvalumab)...

Oncorus Inc (NASDAQ: ONCR) shares slumped after the company reported initial data for its investigational cancer therapy ONCR-177 from a Phase 1 trial in heavily pretreated patients with advanced, injectable solid tumors. ONCR-177 is a Herpes Simplex Virus (HSV) product candidate. In the dose...

In a Phase I study across nine tumor types, Agenus Inc’s (NASDAQ: AGEN) CTLA-4 drug AGN1181 posted one complete response and three partial responses (PRs) as a monotherapy, according to data presented t SITC. The three responders expressed the low-affinity FcγRIIIA...

Shattuck Labs Inc (NASDAQ: STTK) and Takeda Pharmaceutical Co Ltd (NYSE: TAK) mutually agreed to terminate the Collaboration Agreement for SL-279252 and SL-115154. The agreement was initially executed in 2017, under which Takeda had options for up to four molecules. Shattuck...

ALX Oncology Holdings Inc (NASDAQ: ALXO) released additional data from a phase 1b trial of evorpacept in solid tumor malignancies. One cohort included gastric/gastroesophageal junction cancer patients receiving evorpacept plus Roche Holdings AG's (OTC: RHHBY) Herceptin (...

Repare Therapeutics Inc (NASDAQ: RPTX) announced the presentation of preliminary Phase 1 monotherapy data from its Phase 1/2 TRESR trial of RP-3500 for solid tumors with specific synthetic-lethal genomic alterations. Data were presented at the AACR-NCI-EORTC Virtual International...

Turning Point Therapeutics Inc (NASDAQ: TPTX) announced early data from TRIDENT-1 Phase 1/2 study of its lead drug candidate repotrectinib. In the NTRK-positive TKI-naïve advanced solid tumor population (n=17), the confirmed Objective Response Rate (cORR) was 41%.  Three...